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ICN2 Thesis Defence - Zhi Li 
Wednesday, 04 September 2019, 11:00
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PhD:Zhi Li

Director: ICREA Research Professor Josep Nogués and CSIC Tenured Scientist Dr Borja Sepúlveda

Controlled nanotherapies using magneto-plasmonic nanodomes


With the aim of improving the concentration of the therapeutic agents inside tumours and maximizing their therapeutic effects, this Thesis focused on developing novel magneto-plasmonic nanodomes (i.e. dielectric core with plasmonic and ferromagnetic semishells) with combined bottom-up and top-down nanofabrication processes, which enable efficient nanotherapy activation, amplification and control when externally actuated and controlled by light and magnetic fields. Based on this hybrid nanofabrication method, we have achieved to develop three core-semishell nanostructures. Fe/Au nanodomes with fluorescent cores and highly tunable Fe/Au semishells were successfully fabricated for magnetically amplified photothermal therapies and multimodal imaging. Based on the large optomagnetic modulation of highly anisotropic Co/Au multilayer nanodomes, a novel simultaneous heating/thermometer was achieved to gain control over the photothermal effects. In the last chapter, a nearly fully biodegradable drug loaded PLGA@Fe/SiO2 magnetoplasmonic nanocapsules had been developed to maximize the biomedical potentials (nanotherapy, bioimaging and biosensing) for cancer therapies.

In conclusion, we have shown how a hybrid nanofabrication strategy could exploited to develop nanostructures with strong ferromagnetic and plasmonic properties enabling external control and non-invasive visualization. The in vitro and preliminary in vivo results encourage further technological development of this novel nanotechnology for clinical applications.

Location ICN2 Seminar Hall, ICN2 Building, UAB
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