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ICN2 Thesis Defence - David Montpeyó 
Monday, 02 July 2018, 11:00
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PhD: David Montpeyó

Director: Fernando Novio, Julia Lorenzo and Daniel Ruiz-Molina

Nanotechnological strategies for coating and encapsulation of therapeutic proteins


The use of nanotechnologial strategies, such as protein encapsulation and chemical modification of proteins, offer promising expectations to overcome the limitations of protein therapies and improve their therapeutic efficacy.

In this thesis, it has been studied the application of several nanotechnological strategies for protein encapsulation and coating in order to improve the therapeutic value of those proteins. Two proteins were focused; both with therapeutic value in disease treatment, but because of their differences regarding size, structural complexity and enzymatic activity, strategies on each of them need to be addressed particularly. We suggest a strategy for EGF co-encapsulation in PLGA nanoparticles with NvCI, a digestive carboxypeptidase inhibitor, in order to protect it from protease degradation and thus increasing its therapeutic capacity. EGF and NvCI can be successfully encapsulated in PLGA nanoparticles, maintaining its biological activity. Other different approximation was developed for the encapsulation and stabilization of the highly sensitive enzyme Velaglucerase. In this case, Polymer Masked-Unmasked Protein Therapy (PUMPT) strategy was used and developed to mask and preserve the enzyme activity of Velaglucerase until its delivery into the lysosome, where it partially restores the GBA activity levels. PGA conjugation also grants Velaglucerase a higher stability in human blood plasma

Location ICN2 Seminar Hall, ICN2 Building, UAB
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