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Mussel-inspired Self-Sealing Adhesive Biomaterials 
Friday, 12 January 2018, 12:00
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Dr Carlos Carbonell - Postdoctoral Associate Nanoscience Initiative, CUNY Advanced Science Research Center, New York, USA

Mussel-inspired Self-Sealing Adhesive Biomaterials

Short abstract:

Catecholamines are found ubiquitously in nature. Wetting-resistant, adhesive foot-pads in mussels, neurotransmitters in the brain, melanin bio-pigments in the skin and eyes, squid beaks, and insect cuticles are related examples. In materials science, catecholamines have recently attracted significant attention due to the unprecedented material-independent surface-functionalization properties found in poly(dopamine) (pDA)[1] and poly(norepinephrine)[2,3]. The material-independent coating properties are developed only when both catechol and amine moieties coexist in a polymeric backbone. In contrast, when the both moieties are ‘not’ covalently linked, they exhibit self-sealing properties at liquid/air interfaces. The self-sealing requires only O2 in air, and other external stimuli such as light, heat, pH, and moisture as well as internal co- factors such as catalysts are not necessary. Self-sealing conceptually mimics biological healing processes in which precursors at internal liquid are polymerized and/or crosslinked at liquid/air interfaces rather occurring at a bulk liquid. Furthermore, the newly generated material at interfaces robustly attached to existing (i.e. undamaged) one, resulting in sealing properties. As self-sealing utilizes oxygen, regeneration of the catecholamine materials occurs nearly unlimited times as long as the precursor internal solution exists, and more than 100 times of self-sealing was experimentally demonstrated [4]. Finally, this seminar will present a ‘hemostatic needle’ which results in blood vessel self-sealing exhibiting no bleeding after needle withdrawal from tissues [5]

References:

[1] Mussel-inspired Surface Chemistry for Multifunctional Coatings Science 2007, 318, 426-430

[2] Poly(norepinephrine): Ultra-smooth, material-independent surface chemistry and nano-depot for nitric oxide” Angew. Chemie. Int. Ed. 2013, 52, 9187-9191

[3] Norepinephrine: Material-independent, multifunctional surface modification reagent. J. Am. Chem. Soc. 2009, 131, 13224-13225

[4] Biologically inspired materials exhibiting repeatable regeneration with ‘self-sealing’ capabilities without external stimuli or catalysts. Adv. Mater. 2016, http://dx.doi.org/10.1002/adma.201603290

[5] Complete prevention of blood loss with self-sealing hemostatic needles” Nature Materials 2016, http://dx.doi.org/10.1038/nmat4758

 

Location ICN2 Seminar Room
Contact This email address is being protected from spambots. You need JavaScript enabled to view it.
http://icn2.cat/en/events/eventdetail/630/mussel-inspired-self-sealing-adhesive-biomaterials

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